Table 2 Frequency, and intensity of adverse effects observed on 753 patients treated with MDT. There was no statistical significant difference among the study groups for GOT and GPT variation during treatment ( Figure 1). Figure 2 Mean hemoglobin level variation during treatment of 753 patients by group and sex, MDT CT/BR. Considering the other red blood cell results, it was observed that only MCHC did not show statistically significant parameters when the mean average between the different groups during treatment was compared. Although more evident in the PB/U-MDT group, MCV and MCH presented high basal mean increase after the first dose in all groups and remained high during treatment. In MB/U-MDT group, a decrease was observed only after completion of treatment, almost reaching baseline levels; the MB/R-MDT group remained high during all treatment. Figure 3 Patient's risk for anemia according to treatment duration and gender. Table 3 Causes of MDT discontinuation.
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