However, little is known about the expression profiles of sex steroid synthesis and metabolism genes in the natural sex reversal process. HSDs participate in the synthesis and metabolism of sex steroid hormones by catalyzing the conversion of a hydroxy group to a keto group or vice versa on a steroid ring in a specific position and orientation (Yang et al., 2005). Studies on the expression profiles of hsd genes at different stages of grouper sex reversal may provide us a better understanding on the roles of hsd genes in sex reversal. In the gonad, two ( hsd3b1 and hsd17b14 ) and eight ( hsd3b7 , hsd17b1 , hsd17b7l , hsd17b10 , hsd17b12a , hsd17b12b , hsdl1 , and hsdl2 ) β -HSD genes were up- and downregulated during sex reversal, respectively. Hsd3b1 catalyzes the second step of steroidogenesis and is required for the synthesis of all steroids including 11-KT (Hsu et al., 2009). In human testis specimens, HSD17B14 protein has shown immunoreactivity in most of the seminiferous epithelium as well as in peritubular areas harboring Leydig cells (Sivik et al., 2012). Conditional Bet – loterias caixa aposta online a multi bet on irrelevant outcomes. Therefore, we hypothesized that the increased expression levels of hsd3b1 during the sex reversal of grouper may promote the synthesis of 11-KT, while the increased expression level of hsd17b14 may lead to the inactivation of estradiol in this study.
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High dose of corticosteroids might reduce the size of TART [63]. It has been recommended that all patients with CAH should undergo regular testicular examination with ultrasonography [1, 7, 90]. Even though these recommendations were primarily written for 21OHD it can be assumed that males with 3βHSD2D have equal benefits. Supraphysiological glucocorticoid replacement has harmful effects on bone mineral density (BMD) via multiple mechanisms [91, 92]. Only one case of 3βHSD2D and BMD measurements has been reported, and has showed osteoporosis [75]. In general, studies in adults with CAH have demonstrated impaired BMD [4, 93,94,95,96,97,98,99,100], even though there are exceptions with normal BMD [101, 102], and better than other DSD conditions [103]. Your welcome tradução.
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